Carbon nanomaterials sensitize prostate cancer cells to docetaxel and mitomycin C via induction of apoptosis and inhibition of proliferation

• Kati Erdmann,
• Jessica Ringel,
• Silke Hampel,
• Manfred P. Wirth and
• Susanne Fuessel

Beilstein J. Nanotechnol. 2017, 8, 1307–1317, doi:10.3762/bjnano.8.132

• investigates the chemosensitizing potential of CNFs and CNTs to the conventional chemotherapeutics docetaxel (DTX) and mitomycin C (MMC), which have different molecular structures and mechanisms of action than platinum-based chemotherapeutics. DU-145 PCa cells were treated with DTX and MMC alone or in

• . Co-administration of chemotherapeutics with carbon nanomaterials could result in a reduction of the chemotherapeutic dosage and thus limit systemic side effects. Keywords: carbon nanomaterials; chemosensitization; docetaxel; mitomycin C; prostate cancer cells; Introduction According to the global

• mitomycin C (MMC), regarding their cytotoxic effects when applied in combination with carbon nanomaterials. DTX is a cytostatic taxane approved for the palliative treatment of castration-resistant PCa [29]. It promotes microtubule stabilization, acts anti-mitotic and initiates apoptosis resulting in cell